![]() ![]() Inspired by models of chromatin spreading and epigenetic inheritance, we used our system and mathematical models to construct regulatory circuits that induce m6A-dependent transcriptional states, promote their spatial propagation, and maintain epigenetic memory of the states. Our system utilizes synthetic factors that write and read m6A and consequently recruit transcriptional regulators to control reporter loci. Guided by this common principle, we established an orthogonal epigenetic regulatory system in mammalian cells using N6-methyladenine (m6A), a DNA modification not commonly found in metazoan epigenomes. Regulatory networks involving molecular writers and readers of chromatin marks are thought to control these programs. RequestParameters := &graphconfig.Chemical modifications to DNA and histone proteins are involved in epigenetic programs underlying cellular differentiation and development. GraphClient := msgraphsdk.NewGraphServiceClientWithCredentials(cred, scopes) Graphconfig "/microsoftgraph/msgraph-beta-sdk-go/identitygovernance" Msgraphsdk "/microsoftgraph/msgraph-beta-sdk-go" For details about accessing the beta API with the SDK, see Use the Microsoft Graph SDKs with the beta API.įor details about how to add the SDK to your project and create an authProvider instance, see the SDK documentation. Microsoft Graph SDKs use the v1.0 version of the API by default, and do not support all the types, properties, and APIs available in the beta version. The following is an example of a request. Examples Example 1: Retrieve all eligibility schedules Request If successful, this method returns a 200 OK response code and a collection of privilegedAccessGroupEligibilitySchedule objects in the response body. ![]() Request headers Nameĭo not supply a request body for this method. For general information, see OData query parameters. This method supports the $select, $filter, and $expand OData query parameters to help customize the response. GET /identityGovernance/privilegedAccess/group/eligibilitySchedules?filter=principalId eq 'principalId' HTTP request GET /identityGovernance/privilegedAccess/group/eligibilitySchedules?$filter=groupId eq 'groupId' Other roles with permissions to manage groups (such as Exchange Administrators for non-role-assignable Microsoft 365 groups) and administrators with assignments scoped at administrative unit level can manage groups through groups API and override changes made in Azure AD PIM through PIM for groups APIs. The role assignments for the calling user should be scoped at the directory level. For non-role-assignable groups: Global Reader, Directory Writer, Groups Administrator, Identity Governance Administrator, or User Administrator.For role-assignable groups: Global Reader or Privileged Role Administrator.The calling user must also be the owner or member of the group or be assigned one of the following Azure AD roles. Permissions (from least to most privileged) To learn more, including how to choose permissions, see Permissions. One of the following permissions is required to call this API. Get a list of the privilegedAccessGroupEligibilitySchedule objects and their properties. To determine whether an API is available in v1.0, use the Version selector. Use of these APIs in production applications is not supported. APIs under the /beta version in Microsoft Graph are subject to change.
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